Clinical significance of RBM3 expression in surgically treated colorectal lung metastases and paired primary tumors

Abstract Background The lungs are the second most common site of metastases in colorectal cancer (CRC). aim this study was to investigate prognostic factors, including RNA‐binding motif protein 3 (RBM3) expression, patients with CRC treated pulmonary metastasectomy (PM). Methods cohort included all PM at Skåne University Hospital, Lund, Sweden, from 2000 2014. Clinicopathological, treatment, and survival data were collected. Immunohistochemical staining RBM3 evaluated on tissue microarrays samples lung a subset paired primary tumors. Kaplan–Meier analysis Cox proportional hazards modeling applied examine associations investigative factors overall (OS) recurrence‐free survival. Results In total, 216 tumor rectum (57%), left colon (34%), or right (9%) underwent PM. 5‐year OS rate 56%. Age > 60 years, more than one metastasis, size metastasis cm, disease‐free interval < 24 months, low score no adjuvant chemotherapy following for shorter OS. Conclusions Several may be aid selecting as well therapy.